Interactions between HMG boxes

Interactions between HMG boxes.

Many proteins consist of subdomains that can fold and function independently. We investigate here the interaction between the two high mobility group (HMG) box subdomains of the nuclear protein rHMG1. An HMG box is a conserved amino acid sequence of approximately 80 amino acids rich in basic, aromatic and proline side chains that is active in binding DNA in a sequence or structure-specific mann...

HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors.

Formation of the dorsoventral axis in Drosophila melanogaster is mediated through control of the expression of several genes by the morphogen Dorsal. In the ventral part of the embryo Dorsal activates twist and represses zen amongst others. Recently, several proteins have been shown to assist Dorsal in the repression of zen, one of which is DSP1, a HMG box protein that was isolated as a putativ...

Interactions between an HMG-1 protein and members of the Rel family.

We show that the Drosophila protein DSP1, an HMG-1/2-like protein, binds DNA highly cooperatively with three members of the Rel family of transcriptional regulators (NF-kappaB, the p50 subunit of NF-kappaB, and the Rel domain of Dorsal). This cooperativity is apparent with DNA molecules bearing consensus Rel-protein-binding sites and is unaffected by the presence of a negative regulatory elemen...

Exponential S-Boxes: a Link Between the S-Boxes of BelT and Kuznyechik/Streebog

Boxes: A Symbolic Abstract Domain of Boxes

Numeric abstract domains are widely used in program analyses. The simplest numeric domains over-approximate disjunction by an imprecise join, typically yielding path-insensitive analyses. This problem is addressed by domain refinements, such as finite powersets, which provide exact disjunction. However, developing correct and efficient disjunctive refinement is challenging. First, there must be...